Phosphonylmethoxyethyl purine derivatives, a new class of anti-human immunodeficiency virus agents

Inhibition of human immunodeficiency virus by a new class of pyridine oxide derivatives.

A new class of pyridine oxide derivatives as inhibitors of human immunodeficiency virus type 1 (HIV-1) and/or HIV-2 replication in cell culture has been identified. The compounds, which specifically inhibit HIV-1, behave as typical nonnucleoside reverse transcriptase inhibitors (NNRTIs). The most active congener of this group, JPL-133 (UC-B3096), has a 50% effective concentration of 0.05 microg...

Intracellular metabolism and mechanism of anti-retrovirus action of 9-(2-phosphonylmethoxyethyl)adenine, a potent anti-human immunodeficiency virus compound.

9-(2-Phosphonylmethoxyethyl)adenine (PMEA) is a potent and selective inhibitor of retrovirus (i.e., human immunodeficiency virus) replication in vitro and in vivo. Uptake of PMEA by human MT-4 cells and subsequent conversion to the mono- and diphosphorylated metabolites (PMEAp and PMEApp) are dose-dependent and occur proportionally with the initial extracellular PMEA concentrations. Adenylate k...

Human Immunodeficiency Virus (HIV) and Cardiomyopathy: A Systematic Review

Human immunodeficiency virus (HIV) infection has been associated with cardiac disease, including anatomical or functional disturbance to the heart. Cardiomyopathy (CMP) is one of these disturbances that have been associated with high rates of morbidity and mortality. In this review article, several aspects of potential relationships between HIV infection and cardiomyopathy development have been...

synthesis of new 1,3,4-oxadiazole derivatives as anti-hiv agents

Oral Manifestations of Human Immunodeficiency Virus-Infected Patients

Background: Oral lesions are among the earliest clinical manifestations of human immunodeficiency (HIV) infection and are important in early diagnosis and for monitoring the progression to acquired immunodeficiency syndrome (AIDS). The purpose of this study was to determine the prevalence of oral lesions and their relationship with a number of factors in HIV/AIDS patients attending an HIV cente...